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the product information notes that refrigeration can cause a color change (darker yellow) which does not affect safety or effectiveness

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Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8

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Cytotoxic concentrations of alpha-defensins in the lungs of individuals with alpha-1 antitrypsin deficiency and moderate to severe lung disease