Early studies on the role of GSTs in plant biotic stress showed that certain GST genes are specifically up-regulated by microbial infections
Numerous studies have demonstrated the exceptional anti-tumor efficacies of numerous phytochemicals, including baicalin and curcumin, with less adverse effects when compared to other chemotherapy medicines (128)
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Nevertheless, several cellular studies have suggested the protective roles of chemical anti-oxidants, such as GSH, as well as drug metabolizing enzymes, such as NQO1 and UDP-glucuronosyltransferases (UGTs), against AQ-induced cytotoxicity ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds
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Therefore, it is clinically meaningful to assess the level of total erythrocyte GSH as an indicator of GSH status and metabolism