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In this blend they are already combined, and the pairing has a mechanistic rationale: NAD+ supplies the coenzyme, while 5-Amino-1MQ blocks the NNMT enzyme that would otherwise drain NAD+ precursors [4]

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Computational experiments To gain a better understanding of the chemical nature of the linkers and their associated reactivities, computational predictions of the conformational space of the linkers and the warhead within the nucleotide-based inhibitors and KRAS G13C were performed