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When released into bile, they enter the intestines and are meant to leave the body through stool

In large doses, it can cause excessive body stimulation, restlessness, insomnia, increased blood pressure, nervousness, inability to concentrate, headaches, and nosebleeds [218,219]

The gradual increase allows receptor adaptation and gastrointestinal adjustment

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Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia