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10.1016/j.jcmgh.2023.03.001 9 ChiangS

Patients with chronic inflammation (elevated CRP) can have artificially increased ceruloplasmin because it is an acute-phase reactant, masking a true rise in free copper [4]

This is accomplished through the upregulation of key SMAD proteins SMAD2, SMAD3, and SMAD5, serving as intracellular effectors of the TGF- signaling pathway, which is crucial for follicular development, oogenesis, and GCs function

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