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The risk of biliary disease has been examined in fewer studies, which may be because gallbladder emptying is impaired

It is something more uncomfortable: what happens when genuinely promising science encounters a culture optimized for hype, when regulatory frameworks built for pharmaceutical companies fail to anticipate decentralized self-experimentation, and when the financial interests of a grey market align perfectly with the psychological vulnerabilities of people who want to be stronger, younger, leaner, and sharper than they currently are

Many people lose weight and end up looking smaller but not leaner, weaker instead of stronger, or more exhausted than they expected