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Its broad cellular role makes it one of the most widely studied compounds in longevity, dermatology, and metabolic health research

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Annu Rev Pharmacol Toxicol 45, 51-88 (2005)

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A significant advantage of the S , S -tetrazine staple is the ability to introduce probes exploiting inverse electron demand DielsAlder reactions, which make tetrazine staples hold the promise of dual roles: confining peptide conformation and introducing photophysical or other potential probes (Figure 6D) [128]

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