Most studies are based on animal models and in vitro experiments, with small sample sizes that limit statistical power and make the findings susceptible to external objective factors, further affecting their reproducibility and representativeness
Cao S, Hung YW, Wang YC, Chung Y, Qi Y, Ouyang C, Zhong X, Hu W, Coblentz A, Maghami E, et al
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For LCMS analysis, metabolite extracts were analysed by high-resolution mass spectrometry with an Orbitrap Exploris 240 (Thermo) coupled to a Vanquish Flex liquid chromatography system (Thermo)
However, the antitumor effect of monotherapy still cannot satisfy the therapeutic needs due to the disadvantages of TME, such as severe hypoxia condition and overexpressed GSH
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