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Furthermore, botanical drugs modulate autophagy to promote apoptosis (Niazpour and Meshkani, 2025), inhibit HSC activation and hepatocyte apoptosis to counteract hepatic fibrosis (Wang et al., 2024b), and activate SIRT1 to reduce lipid accumulation and ferroptosis (Liu Y

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Yes MK-677 reduces insulin sensitivity by approximately 1015% and raises fasting glucose by 510 mg/dL on average due to sustained growth hormone antagonism of insulin signaling pathways

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