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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

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Here we found that KL1 alone did not induce bacterial outgrowth in the liver, spleen or kidneys, indicating that it did not compromise host immune control over the infection (Extended Data Fig

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