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These included measuring the degree of shortening (contracture) of the operated leg compared to the unoperated one, calculating the walking recovery index (WRI) and the motor function index (MFI), and thigh hypotrophy by comparing the muscle diameter of the operated and non-operated side, as well as measuring the distance between the muscle fibers and anatomical insertion sites for the iliac and femoral bones

The study was supported by the National Institutes of Health, the American Heart Association, the American Diabetes Association and the Juvenile Diabetes Research Foundation

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More aggressive approaches might use three cycles annually, though research supporting increased frequency remains sparse

doi: 10.1016/j.jconrel.2020.11.019

The highest dose currently being studied in major Phase 3 obesity trials is 12mg once weekly