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1e), confirming that loss of function of GLYR1 can partially rescue the hpr1-1 mutant phenotypes

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Angew Chem Int Ed 52(39):1037810383 Yanamandra K, Kfoury N, Jiang H (2013) Anti-tau antibodies block tau propagation

Because MPTP is a lipophilic compound, it can cross the BBB, and be taken up by astrocytes where it is converted to MPP+