Discontinuation due to adverse events was 5.9% on CagriSema vs 3.5% on placebo
Fortunately, you cannot overdose on vitamin B12, as it is water-soluble, so adding more is not harmful
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This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
Consider that immediate can range from a few hours to a day post-injection, depending on the individuals metabolism and overall health
Realistic expectation is improvement of small magnitude
