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At ~504 Da molecular weight with only two amino acid residues (Tyr-Ile core), it falls below the typical size range of bioactive peptides

B12 is unique among vitamins because it requires a complex absorption process

* Correspondence: Susan Birket, [email protected] Lead contact Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1089/ars.2007.1663 Antioxid Redox Signal

This Review provides a synoptic and structured analysis of the current hypotheses about failure in cartilage regeneration, and the accompanying therapeutic strategies to overcome these hurdles, including some current or potential approaches to OA therapy

The question at this stage is whether the incremental benefit over 12.5mg justifies the increased side effect burden