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These strategies, rooted in a deep understanding of ferroptosis biology, hold the potential to revolutionize the management of COPD by moving beyond symptomatic control to directly targeting a core cell death mechanism

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12B) showing complete protection of hair cells against cisplatin in a cochlear explant model with 1.5 hour pretreatment followed by co-treatment of different antioxidants with cisplatin

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Mechanistically, 4-HBGs neuroprotective efficacy against glutamate excitotoxicity has been attributed to competitive inhibition of kainate receptor binding ( 3.6 Brain tissue distribution of GEB extract in normal and MCAO rats Cerebral distribution analysis revealed distinct patterns of six GEB-derived compounds (PA, PB, PC, PE, GAS, 4-HBG) between normal and MCAO rats following oral administration (Figure 8)

Derosa G, Maffioli P, et al