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Mirand, P

Studies have shown that OTA can inhibit the expression of Nrf2 and HO-1 through miR-132 and miR-200c, and induce OTA toxicity by increasing the level of ROS in vitro [18]

Hepatobil Pancreat Dis Int (2016) 15(6):60211

Enhance post-competition recovery by restoring a healthy metabolic rate after prolonged dieting

Lab and animal studies build on this as well, showing the extract reduces inflammatory signals, boosts a protein important for barrier health (filaggrin), and has anti-itch/antibacterial activity (including against C.acnes, the bacteria linked to breakouts)

Many Ishin Premium users who fix their timing see faster improvement in: brightness clarity even tone stress-related dullness 4