Given the muscle weakness that is part of the prime disturbance, vascular failure [66,71,72,73,74,75,76,77,78,79,80,81,82], stroke [20], traumatic brain injury [21], spinal cord compression [28,29], vessel occlusion and similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82] were all specifically highlighted in the literature
The concept of "normal" is based on the middle 95% of results, fitting within a typical bell-shaped curve
Brief exposure for example, during a single research session typically doesnt meaningfully affect the solution, but extended time outside refrigeration accelerates degradation and shortens the usable window described above
It can be a little unpleasant, but it is over within less than a minute
For example, certain drugs that treat multiple sclerosis or rheumatoid arthritis may require self-injection
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