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The mitochondrial mechanism (a redox-cycling alternative electron carrier that feeds cytochrome c oxidase, raising ATP, cerebral oxygen use and blood flow, and crossing the blood-brain barrier easily)

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2 hrs after reaching the maximum plasmatic concentration, the concentration of active drug is higher in the synovial fluid than in the plasma and the rest is reached in a period of 12 hrs

The temperature was set to 30 C and the pH was uncontrolled