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Inflammation cytokines (e.g., TNF-, IL-1) abundant during HIV infection exacerbate mitochondrial dysfunction and ROS production, forming a self-amplifying loop that increases mtDNA damage (85)

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Just as growth hormone regulates not only bone and muscle growth but has much broader functions, DSIP may be a hypothalamic hormone regulating more than just the sleep cycle

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Control Release 366 , 328341 (2024)

It is yet unknown whether other proteins, such as ganglioside-induced differentiation-associated protein-1, actually occupy the GST fold