5-Amino-1MQ balances it, preserving NAD+, improving energy use, repair, fat burning, and inflammation control.[28][29] This inhibition also promotes white-to-brown fat conversion, enhancing thermogenesis and calorie burn
When NNMT becomes overactive, particularly in adipose tissue, it depletes cellular NAD+ reserves while promoting fat storage and metabolic inefficiency
NNMT is an enzyme that grabs nicotinamide and methylates it, turning it into a waste product called 1-MNA that gets cleared from the body
When NAD+ levels are adequate, SIRT1 activity increases, promoting DNA repair, reducing inflammation, and enhancing stress resistance
The right stack depends on the patient's labs, goals, and tolerance
When clinical trial titration data is not available, which is common for peptides like BPC-157 and TB-500 that have not completed human dosing studies, we use the most widely cited community protocols from credible sources and clearly label the evidence tier