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MMP-9 is an ECM protein that has been increasingly implicated in psychiatric disorders, including PTSD (28)
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At a further level of complexity, many nanoplatforms are also engineered to interact with defined immune cell populations or signaling pathways, with the aim of partially relieving immunosuppressive features of the tumor microenvironment and creating conditions more permissive for systemic immunotherapy or rational combination regimens [9, 29, 35]
