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Disruption of redox coupling can be seen in experimental models where astrocyte-specific mutations in the superoxide dismutase gene lead to enhanced motor neuron degeneration, an effect mitigated by mitochondrial-targeted antioxidants like MitoQ ( 4 Sleep disturbances and impaired brain metabolism are closely interconnected, both contributing significantly to the aging process Sleep is an active process initiated and supported by distinct neural populations within the brain

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206 Sleep Sleep disturbance and insomnia is a common feature of anxiety disorders across the lifespan, and the relationship between sleep and anxiety may be bi-directional