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The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B

Reported Tissue Repair and Recovery Research BPC-157 has the most extensive preclinical tissue-repair literature of the four components

doi: 10.1016/j.bbcan.2021.188556

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Those target genes include heme oxygenase 1 (HMOX-1), the main regulator of iron and heme metabolism (Suzen et al., 2022), NAD(P)H quinone dehydrogenase 1 (NQO-1), a reducer of ROS (quinones) (Ross and Siegel, 2021), and peroxiredoxin (PRX), which reduces peroxides (Satoh et al., 2006