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It is found in Asia and Africa, particularly in humid tropical areas (25, 26)
Striatal DAT deficiency is commonly assessed by DAT PET ligands like 11 C-CFT, 18 F-CFT, 11 C-PE2I, and 11 Caltropane, as well as SPECT ligands like 123 I-Iodoflupan and 123 I- CIT, 123 I-FP-CIT, with 99100% sensitivity and specificity in identifying dopamine deficits in the early stages of PD ( 18 F-DOPA, is essential to dopaminergic neurons as it can catalyze the conversion of levodopa into dopamine
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Notably, the combination of autophagy inhibitors (such as chloroquine) and ferroptosis inducers (such as erastin) can significantly inhibit breast cancer proliferation, suggesting the potential of synergistic therapy for dual death pathways [114]
