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A subcutaneous injection creates a local depot from which the compound is absorbed into capillaries and lymphatics over time, generally producing a slower rise and a more gradual exposure than an intravenous bolus
Recently, we demonstrated that the cyclolignan PPP inhibited phosphorylation of IGF-1R without interfering with insulin receptor activity (Girnita et al, 2004), as well as it reduced phosphorylated Akt, caused apoptosis and induced tumour regression in xenografted mice
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