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Further studies showed that berberine enhanced the activities of glutathione peroxidase, glutathione, superoxide dismutase, and catalase, further reducing the activity of acetylcholinesterase and caspase-3, protein carbonyl, and DNA fragmentation in the hippocampus (Sadraie et al., 2019)

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However, if B12 deficiency coexists with androgenetic alopecia (genetic pattern loss), fixing B12 will improve hair quality and reduce excess shedding but won't fully reverse the pattern-driven thinning