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The favorable community experience provides context but cannot definitively answer the cancer safety question that only proper long-term human studies could address

Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation

Trimetazidine improves the outcome of EECP therapy in patients with refractory angina pectoris

The extent to which this impacted lipogenic products (i.e., fatty acids and triglycerides) and whether this was connected to NRF2 activation was unclear

Farquharson J, Adams JF

doi: 10.3389/fneur.2019.01084