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Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)

et al., 2025), and other mechanisms to inhibit NAFLD progression

Some clinics also refer to formulations that include additional compounds as liver detox injections, given the role these nutrients play in supporting hepatic fat metabolism and detoxification

Thomas et al., 2020a)

This critical balance between survival and cell death is orchestrated by the coordinated activity of the three canonical UPR branches, IRE1, PERK, and ATF6, which together determine cell fate decisions under stress