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4 Therapeutic strategies targeting GPX4 for OA 4.1 Drugs directly Inhibiting lipid peroxidation or enhancing GPX4 activity 4.1.1 Classical ferroptosis inhibitors Ferrostatin-1(Fer-1) and Liproxstatin-1(Lip-1) are among the first identified and widely used specific small molecule inhibitors of ferroptosis

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Controlled levels of mitochondria-derived ROS act as signaling molecules during oocyte maturation, activating pathways such as MAPK/ERK to facilitate meiotic progression [33]

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