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Missense variants in FIC-related genes are associated with both PFIC and milder disease forms like BRIC, depending on the specific amino acid alteration and the patients genotypic status (homozygous, compound heterozygous, or heterozygous) [19]

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Possible Side Effects of Glutathione Injections Although glutathione therapy is generally considered safe when administered medically, side effects can occur

Funding This study was supported by the National Natural Science Foundation of China to QZ (No.32270407) and the open fund of State Key Laboratory of Southwestern Chinese Medicine Resources (No.SCMR202103) and Natural Science Foundation of Sichuan (No.2022NSFSC0583) to JL

While the diagnosis of PFIC may start from clinical observation, diagnostic information is required to corroborate clinical suspicion

Reema Arora, patients receive personalised protocols using established medical options such as laser tone correction, chemical peels, topical medical skincare, and regenerative injectables including exosomes (and glutathione where clinically appropriate), guided by AI-assisted skin analysis for precision and safety