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We know buccal absorption of methylcobalamin bypasses the gut, which is relevant when the gut is compromised by GLP-1 therapy

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Doing so can spread bacteria, dirt, and more oil to areas prone to acne and other irritations

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By incorporating protease-cleavable linkers into drug conjugates, it is possible to achieve a high degree of specificity, minimizing off-target effects and enhancing the therapeutic index of the drug

This is particularly significant given that poor vascularity is one of the primary reasons tendons heal so slowly under normal biological conditions