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BPC-157, or Body Protective Compound-157, is a synthetic peptide derived from a protein found in the stomach

TAS, RKC, IK and MH drafted the manuscript

Scientific interest in multi-peptide formulations continues to expand as researchers explore how complementary signaling systems interact across tissue-associated biological processes

Instead, experimental evidence suggests that DSIP interacts indirectly with multiple receptor systems, including components of GABAergic, serotonergic, and opioid-associated pathways [1][2]

The Drugs@FDA database contains no entry for BPC-157 in any indication, and ClinicalTrials.gov shows no ongoing human studies registered in the United States

Transepithelial resistance measurements Caco-2 cells were seeded onto 12 mm polycarbonate membrane inserts (PCF membrane inserts, Millipore, Germany) and bathed in DMEM/F12 medium which contained phenol red, 10% FBS, penicillin (100 units/ml) and streptomycin (10 g/ml)