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Many peptides and proteins face challenges with oral delivery because digestive enzymes break them down before absorption

For many nutrients with pleiotropic effects on different organ systems and multiple biochemical pathways, disease in the whole organism manifests in more than one way and at more than one intake level

It is caused by a genetic mutation in the hemoglobin gene, which leads to misshapen red blood cells that are unstable and less able to transport oxygen to tissues

However, most of these drugs are non-specific or have multiple targets

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doi:10.1016/j.lfs.2006.09.018 Canapp SO Jr, Farese JP, Schultz GS, et al