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The development of this ischemic penumbra is limited in time by a cascade of reactions in response to the initial ischemia followed by subsequent reperfusion

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This makes them water-soluble and able to be excreted through urine or feces.[ref] Essentially, these two steps need to work in tandem: Phase I : The CYP1B1 or CYP1A1 enzyme breaks down estradiol into the catechol estrogen metabolites

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