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The GLA protein in Clone #5 was expected to produce a shorter-than-normal GLA protein due to the early appearance of stop codons
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Maintaining 10 or more rotation sites for frequent dosing allows adequate tissue recovery between injections
10.1007/s11064-021-03322-0 Neurochem Res
ROS, such as superoxide (O 2 - ), can be produced in mitochondrial complexes I and III in components of the tricarboxylic-acid cycle, including -ketoglutarate dehydrogenase (EC 1.2.4.2), and in the outter mitochondrial membrane, damaging cell components such as lipids, proteins and DNA [25, 47]