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According to the Mayo Clinic, nicotine connects to and activates receptors in the cerebral cortex, producing the feel-good brain chemical dopamine

Royal Society of Chemistry

Cotinine has a longer half-life than nicotine, allowing it to be used as a reliable biomarker to detect recent nicotine exposure through urine, blood, or other biological samples

Heat Not Burn (HNB) Tobacco Product Market was valued at USD 13.9 Billion in 2023 and is expected to reach USD 98.9 Billion by the end of 2031, with a CAGR of 27.4% During the Forecast Period 2024-2031

M., Gergalova, G

Alcohol and tobacco products are thus usually subject to state excise taxes