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The MHRA advises following current clinical guidelines, and it signposts to the NICE Clinical Knowledge Summary (CKS) on this topic (NICE, 2022)

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Mistake 2: Squirting water directly onto the powder Directing the stream of bacteriostatic water straight down onto the lyophilized cake creates localized high concentrations and mechanical disruption

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Ravnic DJ, Konerding MA, Tsuda A, Huss HT, Wolloscheck T, Pratt JP, Mentzer SJ

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Drug interactions A number of drugs reduce the absorption of vitamin B 12