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[ 478 ] However, many natural NRF2 agonists are unstable under physiological conditions, with extremely low bioavailability, [ 479 ] and their reactions with cysteine residues are often irreversible, which can cause abnormal and persistent activation of NRF2 and may lead to carcinogenesis, [ 480 ] severely limiting their clinical application
In summary, laboratory rats under ideal laboratory conditions will be more resistant to APAP-induced neurodevelopmental injury than humans that have significant problems metabolizing the drug
Chronic hepatitis: Therapeutic considerations
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PMID 11847309
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