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In addition, harmines suppression of the NF-B signalling pathway inhibits tumour angiogenesis by lowering the production of proangiogenic molecules such as VEGF, NO, and various other factors like IL-2, MMPs, COX-2, and inducible nitric oxide synthase

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(Although the manufacturer does not provide suggestions on daily use amounts, these figures are well within the use range suggested for, and similar to, that of NRT gum