Brain Res 1990;510:104-7
41 In detail, the elevated extracellular ATP induced by SD stress stimulates P2 7 R and down-regulates the expression of 5-HT 2B R by suppressing the activation of AKT, which inhibits the phosphorylation of FoxO3a and promotes its transportation into the nucleus, the reduced 5-HT 2B R alleviates the inhibition of STAT3 to cPLA 2 , the activated cPLA 2 further increases the release of AA and PGE2, these indicators have high relationship with the depressive-like behaviors, because in P2X 7 R knockout mice, the above changes of these indicators and behavioral performance are all eliminated
doi: 10.3389/fimmu.2018.01154 119 PetrocheilouAMoudakiAKaditisAG
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Key Points The FDA announced a recall on iceberg lettuce linked to a Cyclospora outbreak across multiple states
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