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The two allelic variants HET-s and HET-S differ at only 13 amino acids positions and share the same domain architecture with an N-terminal globular HeLo domain and an unstructured C-terminal prion-forming domain (PFD) (Figure 4A) formed by HET-s(218289) has been solved by SSNMR (Figures 4B,C) by Wasmer et al

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