H (400 MHz, MeOD): 7.947.85 (3 H, m, ArH), 7.857.72 (12 H, m, ArH), 4.62 (1 H, dd, J = 9.1, 4.9 Hz, H-4), 4.05 (1H, t, J = 6.4 Hz, H-1), 3.89 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.85 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.513.37 (2 H, m, PCH 2 ), 3.25 (1 H, d, J = 14.7 Hz, H-7 A or B ), 3.192 (1 H, d, J = 14.7 Hz, H-7 A or B ), 3.188 (2 H, d, J = 6.5 Hz, H-8), 3.10 (1 H, dd, J = 14.0, 4.9 Hz, H-5 A or B ), 2.84 (1 H, dd, J = 14.0, 9.1 Hz, H-5 A or B ), 2.59 (2 H, t, J = 7.1 Hz, H-3), 2.352.22 (1 H, m, H-2 A or B ), 2.222.11 (1 H, m, H-2 A or B ),1.761.65 (2 H, m, CH 2 ), 1.661.50 (4 H, m, CH 2 )
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CSD is associated with significant cerebral vasoconstriction (13), which triggers neuronal swelling and activation of meningeal trigeminal nerve endings and the trigeminal vascular system, ultimately contributing to migraine development (1416)
recently demonstrated that the catalytic activity of AOAA-modified CBS can be rescued in the presence of high concentrations of serine (Petrosino et al., 2022)
A notable exception is a recent study by Zheng and colleagues, which found that in a sample of 6785 participants, Fitbit-measured variability of sleep duration and sleep onset time was associated with the risk of MDD 19
