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Abstract Background: Despite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse

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Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms

Japan Association of Molecular Target Therapy Conference, 2012

Despite the fact that some parameters are taken from mice, the developed PBPK model is an important improvement that considers the mechanistic interpretation of metformin pharmacokinetics compared to the current approach where only plasma and/or blood concentrations are taken into account for therapy development