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Firstly, the permeability of EBA increased after 24-h incubation with 3-PLG-ibu, and secondly, in inflammatory condition besides the 3-PLG-ibu-A-GSH the free ibuprofen treated group also significantly strengthened the integrity of the BBB model for the bigger transcellular marker molecule (Fig

2 and Table 3 provide a summary of the known/proposed G-protein coupled receptors mediating the effects of the select neuropeptides

doi: 10.1016/j.biopha.2024.116679 109 HuangYXuWZhouR

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The dosing framework comes from extrapolation: murine studies scaled by body surface area, in vitro keratinocyte studies reverse-engineered to estimate required serum concentration, and anecdotal protocols from research communities using off-label peptides

Glutathione (GSH) is a naturally occurring tri-peptide amino acid that is the second most abundant molecule in the body