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Schirra, J

Chinese Rhubarb (Rheum officinale) Root & Rhizome

M2 macrophages, as infiltration-rich immunosuppressive cells, are able to activate the PI3K/AKT/mTOR signaling axis by secreting IGF-1 and IGF-2, which promotes thyroid cancer cell invasion and the expression of stemness markers (Oct4, SOX2 and CD133), exacerbating the immunosuppressive effects of cancer (74)

After intense exercise, the body often experiences increased free radicals, which can damage muscle cells and lead to inflammation

Crucially, the principle of hormesis dictates that the benefits of hormetins are confined to a low-dose window

PMID: 24097870