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a neurologist later told me B12 deficiency explained both

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173,174 In addition, arginine methylation also affects proteinprotein interactions involved in various cellular processes such as protein trafficking, signal transduction and transcriptional regulation

Another bifunctional TGF- trap fused drug, anti-CTLA4-TGF-RII, showed superior anti-tumour efficacy compared to an anti-CTLA4 antibody alone in preclinical models [336], but its efficacy in patients has not been investigated