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Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene

As expected, the wt strain exhibited increased persistence after oxidative stress induction, consistent with previous reports [8]

For example, changes in the glutathione antioxidant system and disruption in its homeostasis have been implicated in tumor initiation, progression, and treatment response [15]

Glutathione helps manage this process, supporting the liver, protecting cells, helping recycle other antioxidants, and maintaining immune health

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Most of the mutations are leaky so that many patients have residual enzyme activity