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Yang Q, Cleary KR, Yao JC, Swisher SG , Roth JA, Lynch PM, Komaki R, Ajani JA, Rashid A, Hamilton SR, Wu TT

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Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation

Such binding is once again theoretically sufficient, given enough time and the presence free iron, to result in the formation of adducts with the glutathione-like sequences of the receptors present in synapses

This comparison was carried out to clearly assess the contribution of HA surface functionalization to skin permeation and retention relative to the uncoated SLN system