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Blood vessels constrict (narrow) and this decreases blood flow which causes a rise in blood pressure

Hartmann-Boyce J, McRobbie H, Lindson N et al (2021) Electronic cigarettes for smoking cessation

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Our understanding of CSE-induced effects is further complicated by sometimes contradictory results of human studies and experimental set-ups, probably due to the chemical heterogeneity of cigarette smoke, individual genetic susceptibility, and the variability in experimental methodologies (e.g., time, frequency and mode of exposure)