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This negative interaction might be related to the hyperhomocysteinemia-dependent increased thrombotic risk in subjects younger than 46 years and to the low response to the methionine load in older subjects

However, following therapeutic doses, a healthy liver is able to detoxify NAPQI rapidly due to the presence of reduced glutathione (GSH)

Ligibel JA

doi: 10.1016/S0074-7742(07)82016-2

10.1111/bph.13426 112 WongK

Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation